2024 Lexus Rx 350 Hybrid Gas Mileage. Use our handy tool to get estimated annual fuel costs based on your driving habits. 1984 to present buyer's guide to fuel efficient cars and trucks.

The epa’s data shows that the most efficient rx model is the rx350h, which carries claimed ratings of 37 mpg city and 34 mpg highway. The rx 500h, also a hybrid.